Salinomycin reduces the proportion of cancer stem cells (CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug.

Salinomycin Na+ ionophores are metabolized in the liver by cytochrome P450 enzymes, and are excreted mostly into bile and feces as parent compound and metabolites in poultry. Following oral administration, residues are present only at very low concentrations in liver and muscle that fall below the limit of decision of the assay within 2 days in poultry.

Salinomycin sodium salt. Salinomycin (sodium salt) UNII-92UOD3BMEK. 55721-31-8 Type A medicated articles containing 30 or 60 grams of salinomycin activity per pound (as salinomycin sodium biomass). Salinomycin is a membrane ionophore, which shows affinity for alkali ions, preferentially for potassium ions. 2 Salinomycin eases the ion flux through cytoplasmic membrane and the mitochondrial membrane. Salinomycin (SAL) is a veterinary antibiotic used to treat coccidiosis in chicken for more than 30 years (Naujokat et al., 2010). It came on the center stage in cancer drug studies after the revelation of its ability to specifically kill cancer stem cells (CSCs) (Gupta et al., 2009).

Salinomycin

View all Salinomycin is a polyether antibiotic isolated from Streptomyces spp. and a monovalent ionophore for alkali ions with relative K+ selectivity, able thus to interfere Learn more about Salinomycin and get the best prices in the life science marketplace at AG Scientific, Inc. We have over 20 years of experience with Accordingly, we investigated whether salinomycin, a monocarboxylic ionophore, could induce apoptosis in aggressive breast cancer cells or not, as well as its 24 Aug 2019 A few clinical case reports have documented effectiveness of salinomycin in therapy-resistant cancer patients, e.g., a patient with metastatic 25 May 2020 Salinomycin-loaded PLA nanoparticles: drug quantification by GPC and wave voltammetry and biological studies on osteosarcoma cancer stem Unfortunately Salinomycin sodium salt (Cat. No. ) has been withdrawn from sale for commercial reasons. 21 Mar 2018 Sacox® microGranulates, containing salinomycin sodium (SAL-Na), for chickens for fattening and chickens reared for laying have been Salinomycin can induce massive apoptosis in human cancer cells of different origin that display multiple mechanisms of drug and apoptosis resistance. Cell Data Salinomycin (Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic agent. action of salinomycin. Salinomycin shows cyto- toxic effect by disrupting the balance of sodium and potas- sium ions across the cell membrane and the Visit ChemicalBook To find more Salinomycin(53003-10-4) information like chemical properties,Structure,melting point,boiling point,density,molecular formula “To investigate its action, we developed a surrogate salinomycin drug, ironomycin, that was at least 10-fold more potent than salinomycin against CSCs in vitro and Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.

The method is not applicable to drug premixes (pharmaceutical products).

SALINOMYCIN SODIUM. Salinomycin sodium salt. Salinomycin (sodium salt) UNII-92UOD3BMEK. 55721-31-8

It has been used in veterinary medicine as an antimicrobial against Gram negative bacteria and coccidioides. Salinomycin is as an antimicrobial and anticoccidial antibiotic. In 2009, a groundbreaking result was published in the scientific journal Cell (Ref), showing that Salinomycin can be effective in killing the cancer stem cells (CSC), the cancer cell population that is responsible for chemo resistance and metastasis.

Salinomycin (SAL), a broad spectrum antibiotic and a coccidiostat has been found to counter tumour resistance and kill cancer stem cells with better efficacy than the existing chemotherapeutic agents; paclitaxel and doxorubicin. This refocused its importance for treatment of human cancers.

The monensin caused anorexia within 36 hours and difficulty rising 72 hours after feeding. In the salinomycin camel, CK rose to 2580 U/L at 48 hours and 146,000 U/L after 8 days. The monensin-fed camel had CK of 459 U/L on day 5 and 53,900 U/L on day 8. Salinomycin is the key compound in the pharmaceutical company Verastem's efforts to produce an anti-cancer-stem-cell drug. Use in agriculture. Salinomycin is used in chicken feed as a coccidiostat.

Biosynthesis Salinomycin är en fodertillsats av gruppen koccidiostatika som ämnen avsedda att döda eller hindra tillväxten av parasitiska protozoer (encelliga organismer).
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Get best price and read about company. Salinomycin (SAL), a broad spectrum antibiotic and a coccidiostat has been found to counter tumour resistance and kill cancer stem cells with better efficacy 120 grams Salinomycin sodium.

All three drugs inhibited viral replication. Broiler, roaster and replacement (breeder and layer) chickens Use Sacox 60 to provide salinomycin sodium concentrations ranging from 40-60 g/ton (0.0044% to 0.0066%) for the prevention of coccidiosis in broiler, roaster and replacement chickens caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti and E. mivati. Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties.
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2019-05-27

69 p. Salinomycin is a polyether ionophore with broad spectrum Gram positive and anti-coccidial activity. Salinomycin has a high affinity for monovalent cations, particularly potassium. Salinomycin is used to control coccidia in animals and for growth promotion in ruminants. Salinomycin sodium (SAL‐Na) is active against certain Gram‐positive bacteria, while Gram‐negative species are resistant. SAL‐Na at the proposed concentration is unlikely to increase shedding of Salmonella, Escherichia coli and Campylobacter and or induce resistance and cross‐resistance to antimicrobials important in human and animal Unfortunately Salinomycin sodium salt (Cat. No. 3637) has been withdrawn from sale for commercial reasons.